Ketoanalogue-Supplemented Vegetarian Very Low–Protein Diet and CKD Progression

PRODUCT LITERATURE

Ketoanalogue-Supplemented Vegetarian Very Low–Protein Diet and CKD Progression

Garneata L - Personal Name;

Dietary protein restriction may improve determinants of CKD progression. However, the extent of improvement and effect of ketoanalogue supplementation are unclear. We conducted a prospective, randomized, controlled trial of safety and efficacy of ketoanalogue–supplemented vegetarian very low–protein diet (KD) compared with conventional low–protein diet (LPD). Primary end point was RRT initiation or.50%reduction in initial eGFR. Nondiabetic adults with stable eGFR,30 ml/min per 1.73 m2, proteinuria ,1 g/g urinary creatinine, good nutritional status, and good diet compliance entered a run-in phase on LPD. After 3months, compliant patients were randomized to KD (0.3 g/kg vegetable proteins and 1 cps/5 kg ketoanalogues per day) or continue LPD (0.6 g/kg per day) for 15months.

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Aminefron-004

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Language: English
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Content Type: LITERATURE
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Subject(s): Aminefron
Chronic Kidney Disease
Ketoanalogue-Supplemented
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Statement of Responsibility: J Am Soc Nephrol 2016;27

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