PRODUCT LITERATURE
Suprachoroidal Space Triamcinolone Acetonide: A Review in Uveitic Macular Edema
Triamcinolone acetonide injectable suspension for suprachoroidal use (Xipere ® ; SCS triamcinolone acetonide) is a cor-
ticosteroid approved in the USA for the treatment of macular edema associated with uveitis. Suprachoroidal injection of
SCS triamcinolone acetonide results in preferential distribution into the posterior segment, which may reduce the risk of
corticosteroid-related adverse events, such as cataracts and intraocular pressure (IOP) elevation. In a multicenter phase III
trial in patients with non-infectious uveitic macular edema, SCS triamcinolone acetonide significantly and rapidly improved
visual acuity and reduced signs of macular edema compared with sham treatment. SCS triamcinolone acetonide was generally
well tolerated, with the most common adverse event being eye pain on the day of the procedure. The risk of corticosteroid-
related IOP elevation appeared to be reduced in unrescued patients in the SCS triamcinolone acetonide group compared
with patients in the sham control group who received rescue therapy. SCS triamcinolone acetonide is a novel and useful
treatment option for uveitic macular edema.
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