PRODUCT LITERATURE

Dapagliflozin: A Review in Type 2 Diabetes

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Dapagliflozin (
Forxiga®) is a highly potent, reversible and selective sodium-glucose cotransporter-2 inhibitor indicated worldwide
for the treatment of type 2 diabetes (T2D). In the EU, oral dapagliflozin once daily is approved for use as monotherapy (in patients
who are intolerant of metformin) and as add-on combination therapy (with other glucose-lowering agents, including insulin) for
T2D when diet and exercise alone do not provide adequate glycaemic control. In numerous well-designed clinical studies and
their extensions, dapagliflozin as monotherapy and combination therapy with other antihyperglycaemic agents provided effective
glycaemic control and reduced bodyweight and blood pressure (BP) across a broad spectrum of patients. Dapagliflozin reduced
the rate of cardiovascular (CV) death or hospitalization for heart failure (HHF), did not adversely affect major adverse CV events
(MACE) and possibly reduced progression of renal disease relative to placebo in patients with established atherosclerotic CV
disease (CVD) or multiple risk factors for CVD. Dapagliflozin was generally well tolerated, with a low risk of hypoglycaemia;
diabetic ketoacidosis (DKA), although rare, and genital infections were more common with dapagliflozin than placebo. Given
its antihyperglycaemic, cardioprotective and possibly renoprotective properties and generally favourable tolerability profile,
dapagliflozin provides an important option for the management of a broad patient population, regardless of the history of CVD

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Detail Information

Series Title

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Call Number

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Publisher

: .,

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

TEXTBOOK

Media Type

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Carrier Type

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Edition

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Subject(s)

Type 2 Diabetes
Dafoxa
Dapagliflozin

Specific Detail Info

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Statement of Responsibility

Drugs (2019) 79:1135–1146

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