PRODUCT LITERATURE
CHInese Medicine NeuroAiD Efficacy on Stroke Recovery – Extension Study (CHIMES-E): A Multicenter Study of Long-Term Efficacy
The CHInese Medicine NeuroAiD Efficacy on Stroke recovery (CHIMES) study was an international randomized double-blind placebo-controlled trial of MLC601 (NeuroAiD) in subjects with cerebral infarction of intermedi-ate severity within 72 h. CHIMES-E (Extension) aimed at evaluating the effects of the initial 3-month treatment with MLC601 on long-term outcome for up to 2 years.
Methods: All subjects randomized in CHIMES were eligible for CHIMESE. Inclusion criteria for CHIMES were age ≥ 18, baseline National
Institute of Health Stroke Scale of 6–14, and pre-stroke modified Rankin Scale (mRS) ≤ 1. Initial CHIMES treatment allocation
blinding was maintained, although no further study treatment was provided in CHIMES-E.
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