PRODUCT LITERATURE

MLC901, A TRADITIONAL CHINESE MEDICINE INDUCES NEUROPROTECTIVE AND NEUROREGENERATIVE BENEFITS AFTER TRAUMATIC BRAIN INJURY IN RATS

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Traumatic brain injury (TBI) is a frequent and clinically highly heterogeneous neurological disorder with large socioeconomic consequences. NeuroAid (MLC601 and MLC901), a Traditional Medicine used in China for patients after stroke has been previously reported to induce neuroprotection and neuroplasticity. This study was designed to evaluate the neuroprotective and neuroregenerative effects of MLC901 in a rat model of TBI. TBI was induced by a moderate lateral fluid percussion applied to the right parietal cortex.
MLC901 was injected intraperitoneally at 2 h post-TBI, and then administered in drinking water at a concentration of 10 mg/ml until sacrifice of the animals. The cognitive deficits induced by TBI were followed by using the ‘‘whatwhere-when’’ task, which allows the measurement of episodic-like memory. MLC901 treatment decreased brain lesions induced by TBI. It prevented the serum increase of
S-100 beta (S100B) and neuron-specific enolase (NSE), which may be markers to predict the neurologic outcome in human patients with TBI. MLC901 reduced the infarct volume when injected up to 2 h post-TBI, prevented edema formation and assisted its resolution, probably via the regulation of aquaporin 4. These positive MLC901 effects were associated with an upregulation of vascular endothelial
growth factor (VEGF) as well as an increase of endogenous hippocampal neurogenesis and gliogenesis around the lesion.

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: .,

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Language

English

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NONE

Content Type

LITERATURE

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Subject(s)

NeuroAid
Traumatic brain injury
Neurogenesis

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Statement of Responsibility

Neuroscience 277 (2014) 72–86

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