Image of Omeprazole: Effective, Convenient Therapy for Zollinger-Ellison Syndrome

LITERATURE

Omeprazole: Effective, Convenient Therapy for Zollinger-Ellison Syndrome


The acute and long-term effects of omeprazole on gastric acid secretion were examined in 11 patients with Zollinger-Ellison syndrome. Basal gastric acid
secretion was inhibited by 50% 3 h after a single 60-mg dose of omeprazole and 78% 4 h after administration of omeprazole. Patients were treated with a
single daily dose of omeprazole, and the dose requirement was defined as the lowest dose of omeprazole that would reduce gastric acid secretion to < 10
mEq/h during the last hour before the next dose. The mean daily dose requirement was 70 mg (range 20-160 mg). Ten of the 11 patients were given omepra-
zole once a day and 1 patient required omeprazole every 12 h.


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English
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