PRODUCT LITERATURE

Long-term efficacy and safety of otilonium bromide in the management of irritable bowel syndrome: a literature review

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Irritable bowel syndrome (IBS) is a very common functional gastrointestinal disorder characterized by abdominal pain or discomfort and altered bowel habits. The disease affects a large part of the world population. The clinical course is mostly characterized by a cyclic recurrence of symptoms. Therefore, IBS patients should receive, as an initial therapeutic approach, a short course of treatment, and long-term treatment should be reserved for those patients with recurrent symptoms. The available clinical trials show that significant improvement of the symptoms over placebo could be achieved with various drugs, although this improvement is frequently time dependent and with high relapse rates after the cessation of the treatment. In a proportion of patients, clinically obvious relapse could appear long after stopping the treatment. Some of the available pharmacologic agents, including otilonium bromide (OB), are able to significantly prolong the time to the appearance of relapse, compared with placebo

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: .,

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Language

English

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NONE

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Subject(s)

Lonide
Otilonium bromide
Irritable bowel syndrome:

Specific Detail Info

Clinical and Experimental Gastroenterology 2014:7 75–82

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