PRODUCT LITERATURE

Efficacy of otilonium bromide in irritable bowel syndrome: a pooled analysis

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Otilonium bromide (OB) is a spasmolytic agent acting as an L-type calcium channel antagonist in intestinal and colonic smooth muscle cells (SMCs). We analyzed three independent clinical trials with homogeneous design on patients with irritable bowel syndrome (IBS). After 2 weeks receiving placebo, patients were randomized to receive OB (3 × 40 mg daily) or placebo for 15 weeks. We aimed to perform a pooled analysis of the data from these homogeneous clinical trials to evaluate the efficacy of OB treatment on symptoms and global response of patients

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Language

English

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NONE

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Subject(s)

Lonide
Otilonium bromide
Irritable bowel syndrome

Specific Detail Info

Therap Adv Gastroenterol . 2017 Mar;10(3):311-322

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