PRODUCT LITERATURE

Antioxidant and anti-inflammatory properties of a Cucumis melo LC. extract rich in superoxide dismutase activity

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The present studywas conducted to evaluate in vitro and in vivo the antioxidant and anti-inflammatory properties of a cantaloupe melon (Cucumis melo LC., Cucurbitaceae) extract (CME) selected for its high superoxide dismutase activity. Peritoneal macrophages were pre-activated in vitro with 300 IU of interferon-
(IFN-
) and were then challenged in culture with IgGl/anti-IgG1 immune complexes (IgG1IC) in presence of various CME extracts. The subsequent production of free radicals (superoxide anion, nitric oxide, and peroxynitrite) and of pro-(TNF-) and anti-(IL-10) inflammatory cytokines was evaluated. The CME inhibited in a dose-dependent manner the production of superoxide anion with a maximal effect at 100g/ml. This inhibitory effect ofCMEappeared to be closely linked to the SOD activity because itwas dramatically decreased after heat inactivation of the SOD activity (HI-CME).

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: .,

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Language

English

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Classification

NONE

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Subject(s)

Dermapro
Antioxidant

Specific Detail Info

Journal of Ethnopharmacology 94 (2004) 67–75

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