PRODUCT LITERATURE

Effect of ondansetron on nausea and vomiting after middle ear surgery during general anaesthesia

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The efficacy of ondansetron 4 mg and 8 mg was compared with placebo in the reduction of postoperative nausea, retching and vomiting (PONV) after middle ear surgery during general anaesthesia, in 75 patients, in a double-blind and randomized study. Both doses of ondansetron were predictors for a decrease in PONV and the number of doses of rescue antiemetic needed per patient (droperidol: from 0.72 in the placebo group to 0.32 in both the 4-mg and 8-mg groups). No reduction in PONV was observed in patients with a history of motion sickness, whereas in patients without a history of motion sickness, ondansetron reduced both the
proportion of patients suffering from PONV from 53 % to 20 % (P
0.05) and of those needing droperidol from 53 % to 17 %

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Detail Information

Series Title

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Publisher

: .,

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Media Type

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Carrier Type

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Edition

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Subject(s)

Vomiting
Nausea
Ondansetron

Specific Detail Info

British Journal of Anaesthesia 1995; 76: 316–318

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