Image of Effect of ondansetron on nausea and vomiting after middle ear surgery during general anaesthesia

LITERATURE

Effect of ondansetron on nausea and vomiting after middle ear surgery during general anaesthesia


The efficacy of ondansetron 4 mg and 8 mg was compared with placebo in the reduction of postoperative nausea, retching and vomiting (PONV) after middle ear surgery during general anaesthesia, in 75 patients, in a double-blind and randomized study. Both doses of ondansetron were predictors for a decrease in PONV and the number of doses of rescue antiemetic needed per patient (droperidol: from 0.72 in the placebo group to 0.32 in both the 4-mg and 8-mg groups). No reduction in PONV was observed in patients with a history of motion sickness, whereas in patients without a history of motion sickness, ondansetron reduced both the
proportion of patients suffering from PONV from 53 % to 20 % (P  0.05) and of those needing droperidol from 53 % to 17 %


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English
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NONE
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Specific Detail Info
British Journal of Anaesthesia 1995; 76: 316–318
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