PRODUCT LITERATURE

Safety of azithromycin in pediatrics: a systematic review and meta-analysis

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We included 133 studies with 4243 ADRs reported in 197,675 neonates, infants, and children who received azithromycin. The safety of azithromycin as MDA in pediatrics was poorly monitored. The main ADRs were diarrhea and vomiting. In prospective non-MDA studies, the most common toxicity was gastrointestinal ADRs (938/1967; 47.7%). The most serious toxicities were cardiac (prolonged QT or irregular heart beat) and idiopathic hypertrophic pyloric stenosis (IHPS). Compared with placebo, azithromycin did not show increased risk ADRs based on RCTs (risk difference − 0.17 to 0.07). The incidence of QT prolonged was higher in the medium-dosage group (10–30 mg/kg/day) than that of low-dosage group (≤10 mg/kg/day) (82.0% vs 1.2%).

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: .,

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Language

English

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NONE

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Subject(s)

Pediatrics
Iztron
Azithromycin

Specific Detail Info

European Journal of Clinical Pharmacology (2020) 76:1709–1721

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