PRODUCT LITERATURE

Sevoflurane Formulation Water Content Influences Degradation by Lewis Acids in Vaporizers

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Sevoflurane is produced by several manufacturers. Currently marketed sevoflurane formulations differ in their method of synthesis, impurities, containers in which they are sold, and water content. Of the various types of chemical degradation to which sevoflurane is susceptible, the most pertinent is degradation by Lewis acids (such as metal oxides and metal halides) to hydrofluoric
acid and other toxic compounds. Water inhibits such degradation. This observational study determined the degradation profile of three formulations of sevoflurane (two lower-water and one higher-water formulation) when stored in three types of vaporizers

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: .,

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Language

English

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NONE

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Subject(s)

Sevodex
Sevoflurane

Specific Detail Info

Anesth Analg 2009;108:1796 –802

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