PRODUCT LITERATURE

Role of Ketamine in Acute Postoperative Pain Management: A Narrative Review

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The objective of this narrative review was to examine the usage of ketamine as a postoperative analgesic agent across
a wide variety of surgeries. Design. A literature search was performed using the phrases “ketamine” and “postoperative pain.”
The authors analyzed the studies that involved testing ketamine’s effectiveness at controlling postoperative pain. Effectiveness was
assessed through various outcomes such as the amount of opiate consumption, visual analog scale (VAS) pain scores, and persistent
postoperative pain at long-term follow-up. Results. While many different administration protocols were evaluated, delivering
ketamine both as a pre- or perioperative bolus and postoperative infusion for up to 48 hours appeared to be the most effective.
These effects are dose-dependent. However, a number of studies analyzed showed no benefit in using ketamine versus placebo for
controlling postoperative pain.While ketamine is a safe and well-tolerated drug, it does have adverse effects, and there are concerns
for possible neurotoxicity and effects on memory. Conclusions. In a number of limited situations, ketamine has shown some
efficacy in controlling postoperative pain and decreasing opioid consumption. More randomized controlled trials are necessary
to determine the surgical procedures and administrations (i.e., intravenous, epidural) that ketamine is best suited for

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: .,

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Language

English

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Classification

NONE

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Edition

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Subject(s)

Ketamine
Acute Postoperative Pain Management

Specific Detail Info

BioMed Research International Volume 2015, Article ID 749837, 10 pages

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