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Ketamine spares morphine consumption after transthoracic lung and heart surgery without adverse hemodynamic effects

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Thoracotomy is associated with severe pain. Large doses of morphine can depress respiratory drive and compromise hemodynamic stability. Ketamine reduces hyperalgesia, prevents opioid tolerance and resistance and lowers morphine consumption. At sub-anesthetic (≤500g/kg) doses, ketamine rarely produces undesirable hemodynamic alterations. We hypothesized that by combining a sub-anesthetic dose of ketamine with morphine, we could effectively control pain with less morphine and minimize
drowsiness, while maintaining safe hemodynamic and respiratory parameters

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: .,

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Language

English

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NONE

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Subject(s)

Pain
Ketamine HCL

Specific Detail Info

Pharmacological Research 58 (2008) 38–44

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