PRODUCT LITERATURE

The Relationships Between Dose and Antihypertensive Effect of Four AT1-receptor Blockers. Differences in Potency and Efficacy

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The relationships between dose and antihypertensive effect of the first four available AT1-receptor blockers, i.e. losartan, valsartan, irbesartan and candesartan, were assessed based on data obtained from the FDA’s evaluation reports of the respective New Drug Application files. All available randomized, double-blind, placebo-controlled, parallel-group studies in adult men and women with mild to moderate primary diastolic hypertension were included, provided that the reduction in trough (24 h post-dose)
supine or sitting diastolic blood pressure (DBP) had been assessed using the intention-to-treat approach. All studies had an initial single-blind placebo run-in period followed by at least 4 weeks double-blind treatment. The selected studies were included in a meta-analysis of the dose–response relationship for each drug.

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Detail Information

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Publisher

: .,

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Language

English

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Classification

NONE

Content Type

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Carrier Type

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Edition

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Subject(s)

Canderin Duo
Antihypertensive

Specific Detail Info

BLOOD PRESSURE 2002; 11: 293-301

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