PRODUCT LITERATURE

Clopidogrel : A Review of its Use in the Prevention of Thrombosis

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Clopidogrel (Plavix®, Iscover®) selectively and irreversibly inhibits adenosine diphosphate (ADP)-induced platelet aggregation. Long-term administration of clopidogrel was associated with a modest but statistically significant advantage over aspirin in reducing adverse cardiovascular outcomes in patients with established cardiovascular disease in the CAPRIE trial. In other large well designed multicentre trials, such as CURE, COMMIT and CLARITY-TIMI 28, the addition of clopidogrel to aspirin therapy improved outcomes in patients with acute coronary syndromes. However, some issues regarding the use of clopidogrel remain unresolved, such as the optimal loading dose in patients undergoing percutaneous coronary interventions (PCI) and the optimal treatment duration following drug-eluting intracoronary stent placement

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Detail Information

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Publisher

: .,

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Language

English

ISBN/ISSN

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Classification

NONE

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Edition

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Subject(s)

Vaclo
Clopidogrel
Thrombosis

Specific Detail Info

Drugs 2007; 67 (4): 613-646

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