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LITERATURE

Cisapride: A Novel Gastroprokinetic Drug


Impaired gastrointestinal motility underlies a multitude of digestive complaints. Metoclopramide, an antidopaminergic and cholinomimetic agen~ was the first prokinetic drug used to treat such conditions, but a high incidence of adverse effects has limited its use, especially in inf ants. Domperidone, the second prokinetic drug marketed in Canada, is a potent peripheral dopamine receptor antagonist which does not cross the blood-brain barrier well and, therefore, displays minimal CNS side effects. Cisapride is a gastroprokinetic agent which appears to act mainly by releasing acetylcholine from the myenteric plexus of the gut.


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English
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NONE
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The Canadian Journal of Hospital Pharmacy - Volume 44, No. 4, August, 1991
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