PRODUCT LITERATURE

Cisapride: A Novel Gastroprokinetic Drug

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Impaired gastrointestinal motility underlies a multitude of digestive complaints. Metoclopramide, an antidopaminergic and cholinomimetic agen~ was the first prokinetic drug used to treat such conditions, but a high incidence of adverse effects has limited its use, especially in inf ants. Domperidone, the second prokinetic drug marketed in Canada, is a potent peripheral dopamine receptor antagonist which does not cross the blood-brain barrier well and, therefore, displays minimal CNS side effects. Cisapride is a gastroprokinetic agent which appears to act mainly by releasing acetylcholine from the myenteric plexus of the gut.

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Detail Information

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Publisher

: .,

Collation

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Language

English

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Classification

NONE

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Carrier Type

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Edition

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Subject(s)

Cisapride

Specific Detail Info

The Canadian Journal of Hospital Pharmacy - Volume 44, No. 4, August, 1991

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