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LITERATURE

Pharmacokinetic Profile of Cisapride 20 mg After Once- and Twice-Daily Dosing


Cisapride is a substituted piperidinyl benzamide. It is chemically related to metoclopramide but lacks the antidopaminergic
properties of metoclopramide that affect the central nervous system and cause extrapyramidal side effects. Cisapride is indicated
for the symptomatic treatment of patients with nocturnal heartburn due to gastroesophageal reflux disease. Based on extensive assessment of the drug’s pharmacokinetic profile, the currently approved initial oral dosing regimen for cisapride is 10 mg QID.


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Acpulsif-006Available

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English
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NONE
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CLINICAL THERAPEUTICS’VVOL. 20, NO. 2, 1998
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