PRODUCT LITERATURE

Cisapride: What can we learn from the rise and fall of a prokinetic?

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Cisapride, the prototype serotonergic agent, evolved from a body of research that defined the key roles of serotonergic receptors in gastrointestinal motor and sensory function. Impressed by its in vitro properties and encouraged by clinical trial data, cisapride became
the drug of choice for the treatment of a wide range of motility disorders and clinicians appeared impressed by its efficacy and comfortable with its side-effect profile. Once serious cardiac events began to be reported in association with cisapride therapy, dark
clouds rapidly gathered and soon enveloped the drug, leading to its widespread withdrawal from markets

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Detail Information

Series Title

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Publisher

: .,

Collation

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Language

English

ISBN/ISSN

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Classification

NONE

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Edition

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Subject(s)

Acpulsif
Cisapride

Specific Detail Info

Journal of Digestive Diseases 2011; 12; 147–156

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