PRODUCT LITERATURE

Update on Safety Profiles of Vitamins B1, B6, and B12: A Narrative Review

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The neurotropic B vitamins B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) are essential for proper functioning of the nervous system. Deficiencies may induce neurological disorders like peripheral neuropathy (PN) and mainly occur in vulnerable populations
(eg, elderly, diabetics, alcoholics). As epidemiologic cohort studies raised safety concerns about vitamin B6/B12 intake being potentially associated with increased risks of hip fracture (HF) and lung cancer (LC), we explored these aspects and performed comprehensive
literature searches. However, we suggest not to neglect actual high-risk factors (eg, smoking in LC, higher age in HF) by focusing on individual nutrients, but to examine the complex interaction of numerous factors involved in disease development

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: .,

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Language

English

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NONE

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Subject(s)

Vitamin B1
Vitamin B6
Vitamin B12

Specific Detail Info

Therapeutics and Clinical Risk Management 2020:16 1275–1288

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