Image of Population pharmacokinetics and pharmacogenomics of apixaban in Japanese adult patients with atrial fibrillation

LITERATURE

Population pharmacokinetics and pharmacogenomics of apixaban in Japanese adult patients with atrial fibrillation


The nonlinear relationship between oral clearance (CL/F) of apixaban and creatinine clearance (Ccr) was observed. The
population mean of CL/F for a typical patient (Ccr value of 70 ml min1) with the CYP3A5*1/*1 and ABCG2 421C/C or C/A
genotypes was estimated to be 3.06 l h1. When Ccr values were set to the typical value, the population mean of CL/F was 1.52
times higher in patients with the CYP3A5*1/*1 genotype compared with patients with the CYP3A5*1/*3 or *3/*3 genotype, while
the population mean of CL/F was 1.49 times higher in patients with the ABCG2 421C/C or C/A genotype compared with patients
with the ABCG2 421A/A genotype. However, no covariates affected the population mean of the apparent volume of distribution
(Vd/F) of apixaban. The population mean of Vd/F was estimated to be 24.7 l.


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English
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NONE
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Br J Clin Pharmacol (2018) 84 1301–1312
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