PRODUCT LITERATURE

Population pharmacokinetics and pharmacogenomics of apixaban in Japanese adult patients with atrial fibrillation

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The nonlinear relationship between oral clearance (CL/F) of apixaban and creatinine clearance (Ccr) was observed. The
population mean of CL/F for a typical patient (Ccr value of 70 ml min
1) with the CYP3A5*1/*1 and ABCG2 421C/C or C/A
genotypes was estimated to be 3.06 l h
1. When Ccr values were set to the typical value, the population mean of CL/F was 1.52
times higher in patients with the CYP3A5*1/*1 genotype compared with patients with the CYP3A5*1/*3 or *3/*3 genotype, while
the population mean of CL/F was 1.49 times higher in patients with the ABCG2 421C/C or C/A genotype compared with patients
with the ABCG2 421A/A genotype. However, no covariates affected the population mean of the apparent volume of distribution
(Vd/F) of apixaban. The population mean of Vd/F was estimated to be 24.7 l.

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Publisher

: .,

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Language

English

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Classification

NONE

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Edition

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Subject(s)

Apixaban
Pharmacogenomics
Population analysis

Specific Detail Info

Br J Clin Pharmacol (2018) 84 1301–1312

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