PRODUCT LITERATURE

Effect of Apixaban on All-Cause Death in Patients with Atrial Fibrillation: a Meta-Analysis Based on Imputed Placebo Effect

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In these meta-analyses, a lower rate of death was seen both with warfarin (odds ratio [OR] 0.74, 95% confidence interval
[CI] 0.57–0.97) and aspirin (OR 0.86, 95% CI 0.69–1.07) versus placebo/no treatment. Using data from ARISTOTLE and
AVERROES, apixaban reduced the risk of death by 34% (95% CI 12–50%; p = 0.004) and 33% (95% CI 6–52%; p = 0.02),
respectively, when compared with an imputed placebo. The pooled reduction in all-cause death with apixaban compared
with an imputed placebo was 34% (95% CI 18–47%; p = 0.0002).

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Detail Information

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: .,

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Language

English

ISBN/ISSN

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Classification

NONE

Content Type

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Edition

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Subject(s)

Apixaban
Atrial Fibrillation
Aspirin

Specific Detail Info

Cardiovasc Drugs Ther (2017) 31:295–301

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