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Extrapancreatic effects of sulfonylureas - a comparison between glimepiride and conventional sulfonylureas


The contribution of extrapancreatic effects of sulfonylureas to the blood glucose-decreasing activity was reevaluated in vivo and in vitro with several conventional sulfonylureas and with the new one glirnepiride. In vivo, in dogs, after single approximately equipotent blood glucose-decreasing doses, the sulfonylureas were tested for a ranking in the ratios of mean plasma insulin-increasing and blood glucose-decreasing activity. Studies were also performed in hyperglycemic hyperinsulinemic KK-AY mice under once daily treatment for 8 weeks


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English
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NONE
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Diabetes Research and Clinical Practice 28 Suppl, (1995) S115-S137
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