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Extrapancreatic effects of sulfonylureas - a comparison between glimepiride and conventional sulfonylureas

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The contribution of extrapancreatic effects of sulfonylureas to the blood glucose-decreasing activity was reevaluated in vivo and in vitro with several conventional sulfonylureas and with the new one glirnepiride. In vivo, in dogs, after single approximately equipotent blood glucose-decreasing doses, the sulfonylureas were tested for a ranking in the ratios of mean plasma insulin-increasing and blood glucose-decreasing activity. Studies were also performed in hyperglycemic hyperinsulinemic KK-AY mice under once daily treatment for 8 weeks

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: .,

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Language

English

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Classification

NONE

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Subject(s)

Gluvas M
Sulfonylureas

Specific Detail Info

Diabetes Research and Clinical Practice 28 Suppl, (1995) S115-S137

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