THERAPEUTIC CLASS
Systematic Review of Group A Streptococcal emm Types Associated with Acute Post-Streptococcal Glomerulonephritis
Acute post-streptococcal glomerulonephritis (APSGN) is a postinfectious immune-mediated kidney disease
associated with group A Streptococcus (GAS). The prevalence of APSGN varies within and between countries and is influencedby
socioeconomic, host, and bacterial factors. Thedisease ismoreprevalent in developing countries and resource-poor
settings ofdeveloped countries, such as the Indigenous populations residing in tropical Australia. TheM-protein is a universally
present GAS surface antigen that is the focus of molecular typing and vaccine research.
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