THERAPEUTIC CLASS

Disruption of P2X4 purinoceptor and suppression of the inflammation associated with cerebral aneurysm formation

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There are no effective therapeutic drugs for cerebral aneurysms, partly because the pathogenesis remains unresolved. Chronic inflammation of the cerebral arterial wall plays an important role in aneurysm formation, but it is not clear what triggers the inflammation. The authors have observed that vascular endothelial P2X4 purinoceptor is involved in flow-sensitive mechanisms that regulate vascular remodeling. They have thus hypothesized that shear stress–associated hemodynamic stress on the endothelium causes the inflammatory process in the cerebral aneurysm development

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: .,

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Language

English

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Classification

NONE

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Subject(s)

Fibrion
Cardiovascular & Hematopoeiteic System

Specific Detail Info

J Neurosurg 134:102–114, 2021

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