Image of Resisting Resistance: Targeted Therapies in Lung Cancer

LITERATURE

Resisting Resistance: Targeted Therapies in Lung Cancer


Drug resistance inevitably limits the efficacy of all targeted therapies including tyrosine kinase inhibitors (TKIs). Understanding the biological underpinnings of TKI resistance is key to the successful development of future therapeutic strategies. Traditionally, mechanisms of TKI resistance have been viewed under a dichotomous lens. Tumor cells are TKI-sensitive or TKI-refractory, exhibit
intrinsic or acquired resistance, and accumulate alterations within or outside the target to promote their survival. Such classifications facilitate our compre-hension of an otherwise complex biology, but are likely an oversimplification


Availability

REQJ4699Available

Detail Information

Series Title
-
Call Number
-
Publisher : .,
Collation
-
Language
English
ISBN/ISSN
-
Classification
NONE
Content Type
-
Media Type
-
Carrier Type
-
Edition
-
Subject(s)
Specific Detail Info
http://dx.doi.org/10.1016/j.trecan.2016.05.010
Statement of Responsibility

Other version/related

No other version available


File Attachment



Information


RECORD DETAIL


Back To Previous