THERAPEUTIC CLASS

Resisting Resistance: Targeted Therapies in Lung Cancer

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Drug resistance inevitably limits the efficacy of all targeted therapies including tyrosine kinase inhibitors (TKIs). Understanding the biological underpinnings of TKI resistance is key to the successful development of future therapeutic strategies. Traditionally, mechanisms of TKI resistance have been viewed under a dichotomous lens. Tumor cells are TKI-sensitive or TKI-refractory, exhibit
intrinsic or acquired resistance, and accumulate alterations within or outside the target to promote their survival. Such classifications facilitate our compre-hension of an otherwise complex biology, but are likely an oversimplification

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: .,

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Language

English

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NONE

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Subject(s)

Oncology

Specific Detail Info

http://dx.doi.org/10.1016/j.trecan.2016.05.010

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