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A Meta-Analysis of the Effects of Dietary Protein Restriction on the Rate of Decline in Renal Function


Dietary protein restriction has been reported to delay the need for renal replacement therapy in clinical trials and
meta-analyses. However, less clear is what effect dietary protein has on the rate of decline in renal function. We
pooled the results of 13 randomized controlled trials (n 5 1,919 patients) and found that dietary protein restriction
reduced the rate of decline in estimated glomerular filtration rate by only 0.53 mL/min/yr (95% confidence interval
[CI], 0.08 to 0.98 mL/min/yr).We also used weighted regression analysis to determine the reasons for the differences
in the results of these 13 randomized trials along with 11 other nonrandomized controlled trials (n 5 2,248 patients).


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English
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NONE
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American Journal of Kidney Diseases, Vol 31, No 6 (June), 1998: pp 954-961
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