A Meta-Analysis of the Effects of Dietary Protein Restriction on the Rate of Decline in Renal Function

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A Meta-Analysis of the Effects of Dietary Protein Restriction on the Rate of Decline in Renal Function

Kasiske BL - Personal Name;

Dietary protein restriction has been reported to delay the need for renal replacement therapy in clinical trials and
meta-analyses. However, less clear is what effect dietary protein has on the rate of decline in renal function. We
pooled the results of 13 randomized controlled trials (n 5 1,919 patients) and found that dietary protein restriction
reduced the rate of decline in estimated glomerular filtration rate by only 0.53 mL/min/yr (95% confidence interval
[CI], 0.08 to 0.98 mL/min/yr).We also used weighted regression analysis to determine the reasons for the differences
in the results of these 13 randomized trials along with 11 other nonrandomized controlled trials (n 5 2,248 patients).

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Language: English
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Subject(s): Aminefron
Nutrition
Specific Detail Info: American Journal of Kidney Diseases, Vol 31, No 6 (June), 1998: pp 954-961
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