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LITERATURE

Cytokine Storm


The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic has reminded us of the critical role of an effective host immune response and the devastating effect of immune dysregulation. This year marks 10 years since the first description of a cytokine storm that developed after chimeric antigen receptor (CAR) T-cell therapy1 and 27 years since the term was first used in the literature to describe the engraftment syndrome of acute graftversus-host disease after allogeneic hematopoietic stem-cell transplantation.


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REQJ4553-2Available

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English
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NONE
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N Engl J Med 2020;383:2255-73
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