THERAPEUTIC CLASS

The Investigation of Cushing Syndrome: Essentials in Optimizing Appropriate Diagnosis and Management

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The investigation of Cushing syndrome (CS) should start with careful history taking and clinical examination, and exogenous steroid usage must be excluded. It is essential to confirm hypercortisolism before further investigations are undertaken. The recommended first-line tests include midnight salivary cortisol and/or the 1 mg overnight or low-dose dexamethasone suppression tests. The next step is to differentiate adrenocorticotrophin (ACTH)-dependent from ACTH-independent CS by measuring ACTH. With ACTH-dependence, further investigations should differentiate pituitary-dependent from ectopic ACTHdependent CS.

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Publisher

: .,

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Language

English

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Classification

NONE

Content Type

LITERATURE

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Edition

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Subject(s)

Hormones

Specific Detail Info

Ann Saudi Med 2012; 32(5): 455-461

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