THERAPEUTIC CLASS

The genetic basis of ankylosing spondylitis: new insights into disease pathogenesis

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Ankylosing spondylitis (AS) is a complex disease involving multiple risk factors, both genetic and environmental. AS patients are predominantly young men, and the disease is characterized by inflammation and ankylosis, mainly at the cartilage–bone interface and enthesis. HLA-B27 has been known to be the major AS-susceptibility gene for more than 40 years. Despite advances made in the past few years, progress in the search for non-human leukocyte antigen susceptibility genes has been hampered by the heterogeneity of the disease.

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: .,

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Language

English

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NONE

Content Type

LITERATURE

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Subject(s)

FLAMICORT
SINOVIAL
KETESSE
Coxiron
Orinox
Musculo-Skeletal System

Specific Detail Info

The Application of Clinical Genetics 2014:7 105–115

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