THERAPEUTIC CLASS
Intrauterine Growth Restriction: New Insight from the Metabolomic Approach
Recognizing intrauterine growth restriction (IUGR) is a matter of great concern because this condition can significantly afect the newborn’s short- and long-term health. Ever since the first suggestion of the “thrifty phenotype hypothesis” in the last decade of the 20th century, a number of studies have confirmed the association between low birth weight and cardiometabolic syndrome
later in life. During intrauterine life, the growth-restricted fetus makes a number of hemodynamic, metabolic, and hormonal adjustments to cope with the adverse uterine environment, and these changes may become permanent and irreversible
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