THERAPEUTIC CLASS

Newer antibiotics for the treatment of peritoneal dialysis-related peritonitis

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Peritonitis is a debilitating infectious complication of peritoneal dialysis (PD). Drug-resistant bacterial peritonitis typically has a
lower response rate to antibiotics. In the past 15 years, newer antibiotics with activities against drug-resistant Gram-positive
bacteria have been developed. In most circumstances, peritonitis due to methicillin-resistant staphylococci responds to
vancomycin. If vancomycin cannot be used due to allergy and/or non-susceptibility, there is increasing evidence that linezolid
and daptomycin are the drugs of choice. It is reasonable to start linezolid orally or intravenously, but subsequent dose reduction
may be necessary in case of myelosuppression. Daptomycin can be given intravenously or intraperitoneally and has excellent
anti-biofilm activity.

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Detail Information

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Publisher

: .,

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Language

English

ISBN/ISSN

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Classification

NONE

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Edition

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Subject(s)

Anti-infectives

Specific Detail Info

Clinical Kidney Journal, 2016, vol. 9, no. 4, 616–623

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