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LITERATURE

Ceftriaxone : An Update of its Use in the Management of Community-Acquired and Nosocomial Infections


Ceftriaxone is a parenteral third-generation cephalosporin with a long elimination half-life which permits once-daily administration. It has good activity against
Streptococcus pneumoniae, methicillin-susceptible staphylococci, Haemophilus influenzae, Moraxella catarrhalis and Neisseria spp. Although active against
Enterobacteriaceae, the recent spread of derepressed mutants which hyperproduce chromosomal β-lactamases and extended-spectrum β-lactamases
has diminished the activity of all third-generation cephalosporins against these pathogens necessitating careful attention to sensitivity studies.


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English
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NONE
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Drugs 2002; 62 (7): 1041-1089
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