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LITERATURE

Meropenem: A Review of its Antibacterial Activity, Pharmacokinetic Properties and Clinical Efficacy


The parenteral carbapenem meropenem is relatively stable to inactivation by human renal dehydropeptidase (DHP-1) and does not require concomitant administration of a DHP-1 inhibitor such as cilastatin. It has a broad spectrum of antibacterial activity in vitro, the majority of Gram-negative, Gram-positive and anaerobic pathogens being highly susceptible to the drug. Meropenem has shown clinical and bacteriological efficacy in the treatment of a wide range of serious infections in adults and children which is at least comparable with that of currently available treatment options


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Tripenem-001Available

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English
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NONE
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Specific Detail Info
Drugs 50 (l): 73-101, 1995
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