Phosphatidylserine-containing liposomes promote maximal survival of retinal neurons after ischemic injury

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Phosphatidylserine-containing liposomes promote maximal survival of retinal neurons after ischemic injury

Dvoriantchikova G - Personal Name;

We investigated the systemic effect of liposomes bearing apoptotic signals on the level of inflammation and neuronal death induced by ischemia–reperfusion (IR). Using a model of retinal ischemia, we showed that treatment with phosphatidylserine (PS) and
phosphatidylcholine (PC) liposomes significantly reduced the expression of proinflammatory genes, including that of Il1b, Il6,
Ccl2, Ccl5, Cxcl10, and Icam1, 24 h after reperfusion. Phosphatidylserine liposome treatment was the most efficient and correlated with significantly reduced neuronal death in the retina 7 days after reperfusion. The results of our study indicate that therapeutic strategy based on mimicking a systemic increase in apoptotic signaling can significantly reduce central nervous system damage
induced by IR and improve neurologic outcome

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Neulin PS-008

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Language: English
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Subject(s): Neulin PS
Specific Detail Info: Journal of Cerebral Blood Flow & Metabolism (2009) 29, 1755–1759
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