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LITERATURE

Citicoline: neuroprotective mechanisms in cerebral ischemia


Cytidine-5 ¢-diphosphocholine (citicoline or CDP-choline), an intermediate in the biosynthesis of phosphatidylcholine (PtdCho), has shown bene®cial effects in a number of CNS injury models and pathological conditions of the brain. Citicoline improved the outcome in several phase-III clinical trials of stroke, but provided inconclusive results in recent clinical trials.


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English
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NONE
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Specific Detail Info
Journal of Neurochemistry 2002;80:12-23
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