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Changes in Immunological Parameters by Standardized Phyllanthus niruri Extract in the Pre-Clinical and Clinical Studies


One of traditional herbs used as medicine in many countries for various uses is the herb Phyllanthus niruri L. Many pre-clinical studies have explored its activities on the immune system. Further pre-clinical studies were done to determine its safety and immunomodulating characteristics on mice and rats. The results of these studies suggested that Phyllanthus niruri L extract is able to modulate the immune system, via proliferation and activation of T- and Blymphocytes, secretion of specific cytokines such Interferon-gamma, Tumor Necrosis Factor-alpha, and several interleukins, activation of the complement system, activation of phagocytic cells such as macrophages and monocytes, as
well as increase of cytotoxic cells such as the Natural Killer cells


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English
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NONE
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DEXA MEDIA No. 3, Vol. 18, Juli - September 2005
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