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LITERATURE

What is the role of roflumilast in chronic obstructive pulmonary disease?


Roflumilast has been shown to reduce rates of acute exacerbation in patients with severe chronic obstructive pulmonary disease (COPD), ie, forced expiratory volume in 1 second (FEV1) less than 50% with symptoms of chronic bronchitis and a history of exacerbations.

Roflumilast is a selective phosphodiesterase 4 (PDE4) inhibitor that acts on airway smooth muscle cells and various inflammatory cells. By blocking PDE4, roflumilast raises cyclic adenosine monophosphate levels within these cells, curtailing the inflammatory response


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English
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NONE
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CLEVELAND CLINIC JOURNAL OF MEDICINE VOLUME 84 • NUMBER 1 JANUARY 2017
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