PRODUCT LITERATURE

Leukotrienes and airway inflammation

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Asthma is a common chronic inflammatory disease of the airways characterized by airway obstruction and hyperresponsiveness. Leukotrienes (LTs) are lipid mediators that contribute to many aspects of asthma pathogenesis. As the LT pathway is relatively steroid-resistant, its blockade by alternative strategies is a desirable component of asthma management. Cysteinyl LT receptor 1 antagonists have been utilized worldwide for more than 10 years, and while their efficacy in asthma is well accepted, their limitations are also evident. In this review, we summarize the biological effects of LTs in asthma, review recent advances in LT receptors, and consider possible new therapeutic targets in the LT pathway that offer the potential to achieve better control of asthma in the future

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Monarin

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Biochim Biophys Acta. 2011 November ; 1810(11): 1096–1102

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