PRODUCT LITERATURE

Levobupivacaine : A Review of its Pharmacology and Use as a Local Anaesthetic

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The majority of in vitro, in vivo and human pharmacodynamic studies of nerve block indicate that levobupivacaine has similar potency to bupivacaine. However, levobupivacaine had a lower risk of cardiovascular and CNS toxicity than bupivacaine in animal studies. In human volunteers, levobupivacaine had less of a negative inotropic effect and, at intravenous doses >75mg, produced less prolongation of the QTc interval than bupivacaine. Fewer changes indicative of CNS depression on EEG were evident with levobupivacaine

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: .,

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Language

English

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NONE

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Subject(s)

Levica

Specific Detail Info

Drugs 2000 Mar; 59 (3): 551-579

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