THERAPEUTIC CLASS

Vitamin D and the Immune System

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It is now clear that vitamin D has important roles in addition to its classic effects on calcium and bone homeostasis. As the vitamin D receptor is expressed on immune cells (B cells, T cells, and antigenpresenting cells), and these immunologic cells are all capable of synthesizing the active vitamin D metabolite, vitamin D has the capability of acting in an autocrine manner in a local immunologic milieu. Vitamin D can modulate the innate and adaptive immune responses. Deficiency in vitamin D is associated with increased autoimmunity and an increased susceptibility to infection. As immune cells in autoimmune diseases are
responsive to the ameliorative effects of vitamin D, the beneficial effects of supplementing vitamin DYdeficient individuals with autoimmune disease may extend beyond the effects on bone and calcium homeostasis

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: .,

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Language

English

ISBN/ISSN

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Classification

NONE

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Subject(s)

Albuminar

Specific Detail Info

(J Investig Med 2011;59: 881Y886)

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