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LITERATURE

Potential effect of striatin (DLBS0333), a bioactive protein fraction isolated from Channa striata for wound treatment


Striatin contained four major bioactive proteins with approximate molecular weight of 8.3, 10.9, 15.4 and 16.7 kDa. In addition to proteins, striatin also contained amino acids (10 essential and 7 non essential amino acids), fatty acids (palmitic acid, oleic acid, stearic acid, linoleic acid, arachidonic acid), vitamins (vitamin A, vitamin B6) and other nutrients (carbohydrate, dietary fiber, biotin, choline, inositol, L-carnitine, selenium) which are potential for wound healing and increasing serum albumin level.
Treatment with striatin both in vitro and in vivo indicated that striatin enhanced cell proliferation. Wound-induced animal model treated with striatin showed significantly faster wound healing process, as confirmed by wound size and faster serum albumin level recovery. Although striatin does not contain albumin, this bioactive protein fraction may lead to enhanced albumin synthesis in the liver thereby maintaining the blood albumin level. Thus, consuming striatin is a better option to improve albumin levels in diseased condition and the condition of being injured.


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English
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NONE
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Asian Pac J Trop Biomed 2016; 6(12): 1001–1007
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