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Application of Citicoline in Neurological Disorders: A Systematic Review


Citicoline is an abbreviation of cytidine-50 -diphosphocholine (CDP-choline). It is an endogenous chemical compound. Citicoline is globally available as a dietary supplement and in many countries as a drug. It can be bought as a tablet or an injection. In the human body, citicoline is degraded to
cytidine and choline during hydrolysis and dephosphorylation. Subsequently, cytidine and choline are substrates for phosphatidylcholine and CDP-choline synthesis in neurons. However, the detailed mechanism of citicoline functioning is not well understood [1,2]. Citicoline has minimal toxicity and is rapidly metabolized. Products of metabolization are eliminated as carbon dioxide. Citicoline safety has been repeatedly proven in research based on animal


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English
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NONE
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Nutrients 2020, 12, 3113
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