THERAPEUTIC CLASS

Genetics and pathogenesis of systemic lupus erythematosus and lupus nephritis

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Systemic lupus erythematosus (SLE) is a multisystem autoimmune disorder that has a broad spectrum of effects on the majority of organs, including the kidneys. Approximately 40–70% of patients with SLE will develop lupus nephritis. Renal assault during SLE is initiated by genes that breach immune tolerance and promote autoantibody production. These genes might act in concert with other genetic factors that augment innate immune signalling and IFN-I production, which in turn can generate an influx
of effector leucocytes, inflammatory mediators and autoantibodies into end organs, such as the kidneys

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: .,

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Language

English

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NONE

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Subject(s)

Allergy & Immune System

Specific Detail Info

Nat. Rev. Nephrol. 11, 329–341 (2015)

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