Heparin-Induced Thrombocytopenia

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Heparin-Induced Thrombocytopenia

Arepally GM - Personal Name;

Heparin-induced thrombocytopenia (HIT) is an immune complication of heparin therapy caused by antibodies to complexes of platelet factor 4 (PF4) and heparin. Pathogenic antibodies to PF4/heparin bind and activate cellular FcγRIIA on platelets and monocytes to propagate a hypercoagulable state culminating in life-threatening thrombosis. It is now recognized that anti-
PF4/heparin antibodies develop commonly after heparin exposure, but only a subset of sensitized patients progress to life-threatening complications of thrombocytopenia and thrombosis

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REQJ766

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Language: English
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Subject(s): Cardiovascular & Hematopoeiteic System
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