THERAPEUTIC CLASS

Vitamin D Deficiency Modulates Graves’ Hyperthyroidism Induced in BALB/c Mice by Thyrotropin Receptor Immunization

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TSH receptor (TSHR) antibodies and hyperthyroidism are induced by immunizing mice with adenovirus encoding the TSHR or its A-subunit. Depleting regulatory T cells (Treg) exacerbates thyrotoxicosis in susceptible BALB/c mice and induces hyperthyroidism in normally resistant C57BL/6 mice. VitaminDplays an important role in immunity; high dietary vitaminDintake suppresses (and low intake enhances) adaptive immune responses. Vitamin D-induced immunosuppression may enhance Treg. Therefore, we hypothesized that decreased vitamin D intake would mimic Treg depletion and enhance hyperthyroidism induced by A-subunit adenovirus immunization. BALB/c
mice had a reduced ability vs. C57BL/6 mice to generate the active metabolite of vitamin D (1,25- dihydroxyvitamin D3).

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: .,

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English

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NONE

Content Type

LITERATURE

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Subject(s)

Vitamin & Minerals

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