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Spironolactone vs placebo, Bisoprolol, and Doxazin to Determine the Optimal Treatment for drug-resistant Hypertention (PATHWAY-2) : a randomized, double blind, crossover trial.


Optimal drug treatment for patients with resistant hypertension is undefi ned. We aimed to test the hypotheses that resistant hypertension is most often caused by excessive sodium retention, and that spironolactone would therefore be superior to non-diuretic add-on drugs at lowering blood pressure.


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English
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The Lancet
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