THERAPEUTIC CLASS
Redefining lupus nephritis: clinical implications of pathophysiologic subtypes
Systemic lupus erythematosus (SLE) is associated with a broad spectrum of clinical and
immunologic manifestations, of which lupus nephritis is the most common cause of morbidity
and mortality. The development of nephritis in patients with SLE involves multiple pathogenic
pathways including aberrant apoptosis, autoantibody production, immune complex deposition
and complement activation.
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