THERAPEUTIC CLASS
Spironolactone versus placebo, bisoprolol, and doxazosin to determine the optimal treatment for drug-resistant hypertension (PATHWAY-2): a randomised, double-blind, crossover trial
Optimal drug treatment for patients with resistant hypertension is undefi ned. We aimed to test the
hypotheses that resistant hypertension is most often caused by excessive sodium retention, and that spironolactone
would therefore be superior to non-diuretic add-on drugs at lowering blood pressure.
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