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Pathophysiology, Diagnosis and Clinical Management of Hepatorenal Syndrome: From Classic to New Drugs


Advanced cirrhosis is frequently associated with renal dysfunction. Hepatorenal syndrome (HRS) is characterized
by the occurrence of kidney injury in cirrhotic patients in the absence of other identifiable causes. HRS is classified
in 2 different types. Type 1 is characterized by acute renal failure and rapid functional deterioration of other organs, usually
related to a precipitating event. Type 2 is characterized by slowly progressive renal failure and refractory ascites. Advanced
liver disease induces the progression of hemodynamic alterations such as arterial vasodilation of splanchnic circulation
and impairment of cardiac function.


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English
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NONE
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Current Vascular Pharmacology, 2014, 12, 125-135
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